发明申请
- 专利标题： NEUTRALIZING ANTI-INFLUENZA A ANTIBODIES AND USES THEREOF
- 专利标题（中）： 抗中性粒细胞抗体及其用途
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申请号： US15026276申请日： 2014-10-01
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公开(公告)号： US20160257732A1公开(公告)日： 2016-09-08
- 发明人: Ebony Benjamin , Nicole Kallewaard-LeLay , Josephine Mary McAuliffe , Frances Palmer-Hill , Leslie Wachter , Andy Yuan , Qing Zhu , Davide Corti , Antonio Lanzavecchia , Barbara Guarino , Anna DeMarco
- 申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
- 国际申请： PCT/US14/58652 WO 20141001
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; G01N33/577 ; C12P21/00 ; G01N33/569 ; A61K39/42 ; A61K45/06
摘要：
The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.
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