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公开(公告)号：US11932682B2
公开(公告)日：2024-03-19
申请号：US17507482
申请日：2021-10-21
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Ebony Benjamin , Nicole Kallewaard-LeLay , Josephine Mary McAuliffe , Frances Palmer-Hill , Leslie Wachter , Andy Yuan , Qing Zhu , Davide Corti , Antonio Lanzavecchia , Barbara Guarino , Anna DeMarco
IPC分类号： A61K31/13 , A61K31/215 , A61K31/7012 , A61K39/395 , A61K39/42 , A61K45/06 , C07K16/10 , C12P21/00 , G01N33/569 , G01N33/577 , A61K39/00
CPC分类号： C07K16/1018 , A61K31/13 , A61K31/215 , A61K31/7012 , A61K39/3955 , A61K39/42 , A61K45/06 , C12P21/005 , G01N33/56983 , G01N33/577 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N2333/11 , A61K39/3955 , A61K2300/00 , A61K31/215 , A61K2300/00 , A61K31/7012 , A61K2300/00 , A61K31/13 , A61K2300/00
摘要： The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus.
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公开(公告)号：US10519221B2
公开(公告)日：2019-12-31
申请号：US16361653
申请日：2019-03-22
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Nicole Kallewaard-Lelay , Qing Zhu , Ebony Benjamin , Leslie Wachter , Andy Yuan , Josephine Mary McAuliffe , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K16/10 , G01N33/569 , A61K39/00
摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
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公开(公告)号：US11787853B2
公开(公告)日：2023-10-17
申请号：US17499495
申请日：2021-10-12
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Nicole Kallewaard-Lelay , Qing Zhu , Ebony Benjamin , Leslie Wachter , Andy Yuan , Josephine Mary Mcauliffe , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K16/10 , A61P31/16 , G01N33/569 , A61K39/00
CPC分类号： C07K16/1018 , A61P31/16 , G01N33/56983 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2333/11 , G01N2469/10
摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
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公开(公告)号：US20220033480A1
公开(公告)日：2022-02-03
申请号：US17507482
申请日：2021-10-21
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Ebony Benjamin , Nicole Kallewaard-LeLay , Josephine Mary McAuliffe , Frances Palmer-Hill , Leslie Wachter , Andy Yuan , Qing Zhu , Davide Corti , Antonio Lanzavecchia , Barbara Guarino , Anna DeMarco
IPC分类号： C07K16/10 , A61K31/13 , A61K39/395 , A61K31/7012 , A61K31/215 , A61K39/42 , A61K45/06 , C12P21/00 , G01N33/569 , G01N33/577
摘要： The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus.
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公开(公告)号：US10294292B2
公开(公告)日：2019-05-21
申请号：US15325603
申请日：2015-07-14
申请人： MedImmune, LLC , HUMABS BIOMED SA
发明人： Nicole Kallewaard-LeLay , Qing Zhu , Ebony Benjamin , Leslie Wachter , Andy Yuan , Josephine Mary McAuliffe , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K16/10 , G01N33/569 , A61K39/00
摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
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公开(公告)号：US11186627B2
公开(公告)日：2021-11-30
申请号：US16596039
申请日：2019-10-08
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Ebony Benjamin , Nicole Kallewaard-LeLay , Josephine Mary McAuliffe , Frances Palmer-Hill , Leslie Wachter , Andy Yuan , Qing Zhu , Davide Corti , Antonio Lanzavecchia , Barbara Guarino , Anna DeMarco
IPC分类号： A61K31/13 , A61K39/42 , A61K45/06 , C07K16/10 , A61K39/395 , A61K31/7012 , A61K31/215 , C12P21/00 , G01N33/569 , G01N33/577 , A61K39/00
摘要： The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.
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公开(公告)号：US11174304B2
公开(公告)日：2021-11-16
申请号：US16676974
申请日：2019-11-07
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Nicole Kallewaard-Lelay , Qing Zhu , Ebony Benjamin , Leslie Wachter , Andy Yuan , Josephine Mary McAuliffe , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K16/10 , A61P31/16 , G01N33/569 , A61K39/00
摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
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公开(公告)号：US20160257732A1
公开(公告)日：2016-09-08
申请号：US15026276
申请日：2014-10-01
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Ebony Benjamin , Nicole Kallewaard-LeLay , Josephine Mary McAuliffe , Frances Palmer-Hill , Leslie Wachter , Andy Yuan , Qing Zhu , Davide Corti , Antonio Lanzavecchia , Barbara Guarino , Anna DeMarco
IPC分类号： C07K16/10 , G01N33/577 , C12P21/00 , G01N33/569 , A61K39/42 , A61K45/06
CPC分类号： C07K16/1018 , A61K31/13 , A61K31/215 , A61K31/7012 , A61K39/3955 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/56983 , G01N33/577 , G01N2333/11 , A61K2300/00
摘要： The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus. In one embodiment, an antibody or binding fragment according to the invention is capable of binding to and/or neutralizing one or more influenza A virus group 1 subtypes selected from H1, H2, H5, H6, H8, H9, H11, H12, H13, H16 and H17 and variants thereof and one or more influenza A virus group 2 subtype selected from H3, H4, H7, H1, 0, H14 and H15 and variants thereof.
摘要翻译： 本发明涉及能够结合甲型流感病毒血凝素并中和至少一种亚型1型和至少1型亚型甲型流感病毒的抗体及其结合片段。 在一个实施方案中，根据本发明的抗体或结合片段能够结合和/或中和选自H1，H2，H5，H6，H8，H9，H11，H12，H13的一种或多种甲型流感病毒1型亚型 ，H16和H17及其变体和选自H3，H4，H7，H1，0，H14和H15的一种或多种甲型流感病毒2型亚型及其变体。
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公开(公告)号：US20170218054A1
公开(公告)日：2017-08-03
申请号：US15325603
申请日：2015-07-14
申请人： Medlmmune, LLC , HUMABS BIOMED SA
发明人： Nicole Kallewaard-LeLay , Qing Zhu , Ebony Benjamin , Leslie Wachter , Andy Yuan , Josephine Mary McAuliffe , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
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