Invention Application
- Patent Title: Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
-
Application No.: US15000522Application Date: 2016-01-19
-
Publication No.: US20160304928A1Publication Date: 2016-10-20
- Inventor: William YANG , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Tsang , Thomas Ryll
- Applicant: Biogen MA Inc.
- Applicant Address: US MA Cambridge
- Assignee: Biogen MA Inc.
- Current Assignee: Biogen MA Inc.
- Current Assignee Address: US MA Cambridge
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N5/00
Abstract:
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
Public/Granted literature
- US09944968B2 Control of protein glycosylation by culture medium supplementation and cell culture process parameters Public/Granted day:2018-04-17
Information query
