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公开(公告)号：US20160304928A1
公开(公告)日：2016-10-20
申请号：US15000522
申请日：2016-01-19
Applicant: Biogen MA Inc.
Inventor： William YANG , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Tsang , Thomas Ryll
CPC classification number: C12P21/005 , C12N5/0018 , C12N2500/20 , C12N2500/30 , C12N2500/34 , C12N2500/40 , C12N2500/90 , C12N2501/04 , C12N2511/00
Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
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2.发明申请公开(公告)号：US20190085369A1
公开(公告)日：2019-03-21
申请号：US15953746
申请日：2018-04-16
Applicant: Biogen MA Inc. , Samsung Bioepis
Inventor： William C. Yang , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Liu Tsang , Thomas Ryll , Sangil Lee , Dae Sung Lee
CPC classification number: C12P21/005 , C12N5/0018 , C12N2500/20 , C12N2500/30 , C12N2500/34 , C12N2500/40 , C12N2500/90 , C12N2501/04 , C12N2511/00
Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
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Patent Agency Ranking
公开(公告)号：US11124760B2
公开(公告)日：2021-09-21
申请号：US15128732
申请日：2015-03-24
Applicant: Biogen MA Inc. , Samsung Bioepis
Inventor： William Yang , Yao-Ming Huang , Marty Sinacore , Thomas Ryll , Jiuyi Lu , Jaesun Lee , Kyngju Lee , Hyoung Taek Lim , Eunchong Yang
Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
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4.发明申请Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters 审中-公开通过培养基补充和细胞培养过程参数控制蛋白质糖基化公开(公告)号：US20160237399A1
公开(公告)日：2016-08-18
申请号：US14625559
申请日：2015-02-18
Applicant: Biogen MA Inc.
Inventor： William YANG , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Tsang , Thomas Ryll
CPC classification number: C12P21/005 , C12N5/0018 , C12N2500/20 , C12N2500/30 , C12N2500/34 , C12N2500/40 , C12N2500/90 , C12N2501/04 , C12N2511/00
Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
Abstract translation: 本发明涉及包含培养基补充物的细胞培养基，其显示为控制或调节（转移）温度中的重组蛋白糖基化和/或细胞培养以控制具有受控或调节的种子密度的重组蛋白糖基化和/或细胞培养 以控制重组蛋白糖基化，及其使用方法。 本发明还涉及在大规模细胞培养物中控制或操纵感兴趣的重组蛋白质的糖基化的方法。
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公开(公告)号：US20220213431A1
公开(公告)日：2022-07-07
申请号：US17401558
申请日：2021-08-13
Applicant: BIogen MA Inc. , Samsung Bioepis
Inventor： William C. Yang , Yao-Ming Huang , Marty Sinacore , Thomas Ryll , Jiuyi Lu , Jaesun Lee , Kyngju Lee , Hyoung Taek Lim , Eunchong Yang
Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
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公开(公告)号：US10676772B2
公开(公告)日：2020-06-09
申请号：US15953746
申请日：2018-04-16
Applicant: Biogen MA Inc. , Samsung Bioepis
Inventor： William C. Yang , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Liu Tsang , Thomas Ryll , Sangil Lee , Dae Sung Lee
Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
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公开(公告)号：US09944968B2
公开(公告)日：2018-04-17
申请号：US15000522
申请日：2016-01-19
Applicant: Biogen MA Inc. , Samsung Bioepis
Inventor： William Yang , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Tsang , Thomas Ryll , Sangil Lee , Dae Sung Lee
CPC classification number: C12P21/005 , C12N5/0018 , C12N2500/20 , C12N2500/30 , C12N2500/34 , C12N2500/40 , C12N2500/90 , C12N2501/04 , C12N2511/00
Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
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