Invention Application
- Patent Title: TRICYCLIC SULFONES AS RORy MODULATORS
- Patent Title (中): TRICYCLIC SULFONES作为RORY调制器
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Application No.: US15148209Application Date: 2016-05-06
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Publication No.: US20160326195A1Publication Date: 2016-11-10
- Inventor: Jingwu Duan , T.G. Murali Dhar , David Marcoux , Qing Shi , Douglas G. Batt , Qingjie Liu , Robert J. Cherney , Lyndon A.M. Cornelius , Anurag S. Srivastava , Myra Beaudoin Bertrand , Carolyn A. Weigelt
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Main IPC: C07F9/6574
- IPC: C07F9/6574 ; C07D221/10 ; C07D401/06 ; C07D209/70 ; C07D409/06 ; C07D491/052 ; C07D401/12 ; C07D403/06 ; C07D417/06 ; C07D493/08 ; C07D405/06 ; C07D413/10 ; C07D413/06 ; C07D471/04 ; C07D417/14 ; C07D495/04 ; C07D495/08 ; C07D417/12 ; C07D413/12 ; C07D403/12 ; C07D491/107 ; C07D209/60

Abstract:
There are described RORγ modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US09815859B2 Tricyclic sulfones as RORγ modulators Public/Granted day:2017-11-14
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