Invention Application
- Patent Title: ANTIDIABETIC COMPOUNDS
- Patent Title (中): 抗菌化合物
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Application No.: US15110894Application Date: 2015-02-03
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Publication No.: US20160332968A1Publication Date: 2016-11-17
- Inventor: Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Michael Yang
- Applicant: Harry CHOBANIAN , Duane DEMONG , Yan Guo , Zhiyong Hu , Barbara PIO , Christopher PLUMMER , Dong XIAO , Cangming YANG , Rui ZHANG , Merck Sharp & Dohme Corp. , Michael MILLER
- International Application: PCT/US15/14153 WO 20150203
- Main IPC: C07D211/42
- IPC: C07D211/42 ; C07D211/22 ; C07D205/04 ; C07D209/54 ; C07D209/52 ; C07D207/12 ; C07D205/12 ; C07C217/52 ; C07D401/04 ; C07D265/30 ; C07C59/72 ; C07D213/64 ; C07D213/69 ; C07D239/52 ; C07D231/20 ; C07D307/88 ; C07D491/056 ; C07D307/86 ; C07D213/30 ; C07D213/647 ; C07D207/08

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US10059667B2 Antidiabetic compounds Public/Granted day:2018-08-28
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