- 专利标题： TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION
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申请号： US15051907申请日： 2016-02-24
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公开(公告)号： US20160340692A1公开(公告)日： 2016-11-24
- 发明人: Pin Wang , Lili Yang , David Baltimore
- 申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; A61K35/76 ; A61K38/17 ; A61K38/19 ; A61K38/20 ; A61K39/21 ; C12N7/00 ; C07K14/005
摘要：
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
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