Invention Application
US20160355560A1 NETRIN-1 AND DEPENDENCE RECEPTOR PROTEINS AND METHODS OF USE
审中-公开
NETRIN-1和依赖性受体蛋白及其使用方法
- Patent Title: NETRIN-1 AND DEPENDENCE RECEPTOR PROTEINS AND METHODS OF USE
- Patent Title (中): NETRIN-1和依赖性受体蛋白及其使用方法
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Application No.: US15117863Application Date: 2015-02-10
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Publication No.: US20160355560A1Publication Date: 2016-12-08
- Inventor: Jorg Stetefeld
- Applicant: Jorg STETEFELD , UNIVERSITY OF MANITOBA
- International Application: PCT/IB2015/050992 WO 20150210
- Main IPC: C07K14/475
- IPC: C07K14/475 ; C07K16/18
Abstract:
Provided herein are fragments of Netrin-1 proteins, fragments of DCC proteins and NEO1 proteins, and antibodies to epitopes located within the fragments of Netrin-1, DCC, and/or NEO1. Also provided herein are methods for using the fragments and antibodies, including methods for inhibiting binding of Netrin-1 to an UNC5 protein, a DCC protein, and/or a NEO1 protein. Other methods provided herein include inducing apoptosis of a cell, and reducing formation of multimers of Netrin-1 proteins, and treating a subject having a cancer or at risk of having a cancer.
Information query
