公开(公告)号：US20160355560A1

公开(公告)日：2016-12-08

申请号：US15117863

申请日：2015-02-10

Applicant: Jorg STETEFELD ,  UNIVERSITY OF MANITOBA

Inventor： Jorg Stetefeld

IPC: C07K14/475 ,  C07K16/18

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K14/70503 ,  C07K16/18 ,  C07K2317/34 ,  C07K2319/00

Abstract: Provided herein are fragments of Netrin-1 proteins, fragments of DCC proteins and NEO1 proteins, and antibodies to epitopes located within the fragments of Netrin-1, DCC, and/or NEO1. Also provided herein are methods for using the fragments and antibodies, including methods for inhibiting binding of Netrin-1 to an UNC5 protein, a DCC protein, and/or a NEO1 protein. Other methods provided herein include inducing apoptosis of a cell, and reducing formation of multimers of Netrin-1 proteins, and treating a subject having a cancer or at risk of having a cancer.

Abstract translation: 本文提供了Netrin-1蛋白的片段，DCC蛋白和NEO1蛋白的片段，以及位于Netrin-1，DCC和/或NEO1片段内的表位的抗体。 本文还提供了使用片段和抗体的方法，包括用于抑制Netrin-1与UNC5蛋白，DCC蛋白和/或NEO1蛋白的结合的方法。 本文提供的其它方法包括诱导细胞凋亡，并减少Netrin-1蛋白多聚体的形成，以及治疗患有癌症或有癌症风险的受试者。