Invention Application
US20170002008A1 BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
有权
具有选择性活性的双环胺取代的N-苯并呋喃胺化合物在电压筛选的钠通道中
- Patent Title: BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
- Patent Title (中): 具有选择性活性的双环胺取代的N-苯并呋喃胺化合物在电压筛选的钠通道中
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Application No.: US15038805Application Date: 2014-11-24
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Publication No.: US20170002008A1Publication Date: 2017-01-05
- Inventor: Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
- Applicant: Dansu LI , Mark E. LAYTON , Anthony J. ROECKER , Melissa EGBERTSON , Kristen L. G. JONES , Xiu WANG , Xuanjia PENG , MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Priority: CNPCT/CN2013/001476 20131129
- International Application: PCT/US14/67001 WO 20141124
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D487/10 ; C07D471/04 ; C07D285/135 ; C07D213/76 ; C07D239/42 ; C07D237/20 ; C07D491/20 ; C07D277/52
Abstract:
Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
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