发明申请
US20170002338A1 OMEGA-TRANSAMINASE OF R CONFIGURATION AND USES THEREOF
审中-公开
R配置的OMEGA-TRANSAMINASE及其用途
- 专利标题： OMEGA-TRANSAMINASE OF R CONFIGURATION AND USES THEREOF
- 专利标题（中）： R配置的OMEGA-TRANSAMINASE及其用途
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申请号： US15039736申请日： 2014-10-29
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公开(公告)号： US20170002338A1公开(公告)日： 2017-01-05
- 发明人: Hao HONG , Feng GAO , Yanjun LI , Yan ZHANG , Shaohe LI
- 申请人： ASYMCHEM LABORATORIES (TIANJIN) CO., LTD , ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD , TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD , ASYMCHEM LABORATORIES (FUXIN) CO., LTD , JILIN ASYMCHEM LABORATORIES CO., LTD
- 优先权： CN201310610701.2 20131126
- 国际申请： PCT/CN2014/089845 WO 20141029
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12P13/00 ; C12P17/12
摘要：
An omega-transaminase of R-configuration is provided. The omega-transaminase of R-configuration has the amino acid sequence as shown in SEQ ID NO: 2, or has at least 80% identity to the amino acid sequence as shown in SEQ ID NO: 2, or has the amino acid sequence of proteins which have substituted, deleted or added one or more amino acids and have the activity of an omega-transaminase with a high stereoselectivity R-configuration catalytic activity; and does not have the amino acid sequence encoded by the nucleotide sequence as shown in SEQ ID NO: 4. The high stereoselectivity refers to the content of one of the stereoisomers being at least about 1.1 times that of the other. A use of the omega-transaminase of R-configuration is provided.
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