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    Preparation process of diazomethane
    1.
    发明授权
    Preparation process of diazomethane 有权

    公开(公告)号：US12084402B2

    公开(公告)日：2024-09-10

    申请号：US17611712

    申请日：2019-05-21

    Applicant: ASYMCHEM LABORATORIES (TIANJIN) CO., LTD.

    Inventor： Hao Hong ,  Jiangping Lu ,  Enxuan Zhang ,  Wei Shen ,  Honglei Yan ,  Zhen Zhang

    IPC: C07C245/16

    CPC classification number: C07C245/16

    Abstract: Provided is a preparation process of diazomethane. The preparation process includes: step S1, taking N-methylurea as a raw material to continuously prepare, in a continuous reactor, a first product system containing N-methyl-N-nitrosourea: step S2, performing continuous extraction and continuous back-extraction on the first product system to obtain an N-methyl-N-nitrosourea solution; step S3, enabling the N-methyl-N-nitrosourea solution to continuously react with an alkaline solution in a continuous reactor to obtain a second product system containing the diazomethane; and step S4, performing continuously liquid separation, water freezing and removal on the second product system, to obtain the diazomethane.

    TRANSAMINASE MUTANT AND USE THEREOF
    2.
    发明公开
    TRANSAMINASE MUTANT AND USE THEREOF 审中-公开

    公开(公告)号：US20230227797A1

    公开(公告)日：2023-07-20

    申请号：US17769204

    申请日：2019-10-28

    Applicant: ASYMCHEM LABORATORIES (TIANJIN) CO., LTD.

    Inventor： Hao HONG ,  Gage JAMES ,  Yi XIAO ,  Yulei MA ,  Na ZHANG ,  Xuecheng JIAO ,  Huiyan MU ,  Yibing CHENG ,  Shan CAO

    IPC: C12N9/10 ,  C12P13/00

    CPC classification number: C12N9/1096 ,  C12P13/001

    Abstract: Provided are a transaminase mutant and use thereof. The transaminase mutant has an amino acid sequence obtained by mutation of an amino acid sequence shown in SEQ ID NO:1, the mutation at least includes one of the following mutation site combinations: T7C+S47C, Q78C+A330C, V137C+G313C, A217C+Y252C and L295C+C328C; or the transaminase mutant has an amino acid sequence which has the mutation sites in the mutated amino acid sequence and has 80% or more identity with the mutated amino acid sequence. The transaminase mutant realizes the change of protein structure and functions, reduces the enzyme amount, increases the enantiomeric excess (ee) value of a product, and reduces the difficulty of post-processing, so that the transaminase mutant may be suitable for industrial production.

    Method and Device for Continuously Synthesizing Cyclopropane Compounds
    4.
    发明申请
    Method and Device for Continuously Synthesizing Cyclopropane Compounds 有权

    公开(公告)号：US20220242805A1

    公开(公告)日：2022-08-04

    申请号：US17622294

    申请日：2019-07-02

    Applicant: ASYMCHEM LABORATORIES (TIANJIN) CO., LTD.

    Inventor： Hao HONG ,  Jiangping LU ,  Xichun FENG ,  Xingfang SUN ,  Feng ZHANG

    IPC: C07C2/86 ,  C07B37/02

    Abstract: The present disclosure discloses a method and a device for continuously synthesizing cyclopropane compounds. The method includes the following steps: continuously performing a synthetic reaction of a diazomethane precursor in a first reactor, the reaction product of the first reactor flowing into a separator for stratification, the organic phase obtained by stratification overflowing into a second reactor, continuously consuming the diazomethane precursor in a second reactor to prepare diazomethane and performing an electron-rich monoolefin cyclopropanation reaction in situ so as to obtain the cyclopropane compound. The technical solution of the present disclosure may be applied to achieve automatic control, decrease the transfer of high-risk materials, and prevent the risk of pipeline transfer of diazomethane solution, and effectively improve production safety. Moreover, the present disclosure provides a simple device to save equipment investment, and may safely and quantitatively achieve the production of diazomethane and the cyclopropanation reaction of olefins simultaneously.

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