A system and process for detecting dynamic segregation in concrete rotated within a mixer drum, such as mounted on a delivery truck. A system processor is programmed to monitor an instantaneous and averaged rheology parameter (e.g., instantaneous and averaged slump values) and to deploy one or more protocols for detecting the occurrence of segregation. A first protocol comprises monitoring the averaged slump or other rheology value of concrete during and immediately after a jump in drum speed of at least plus or minus four rotations per minute and detecting when a change in the averaged slump value meets or exceeds a threshold limit pre-selected by the user or the system processor; and an optional second protocol comprises monitoring the instantaneous slump or other rheology value of the concrete when the mixer drum is rotating at a constant speed for at least three successive rotations.