An expanding locating and clamping pin assembly configured to locate and clamp a part includes a housing, a locating pin, an actuating mechanism, and a controller. The housing is configured with a plurality of radial jaw guides and a part rest face. The locating pin has a plurality of jaws radially movable in the radial jaw guides, extending past the part rest face, and configured with a part clamping feature. The actuating mechanism is connected to the housing and the jaws and is configured to synchronously move the jaws to a radial position and to apply the clamping force. The controller controls the radial position of the jaws and the clamping force. The part rest face and the jaws of the locating pin are configured to receive the part in a located position and to clamp the part in the located position via the clamping force.