A clamp device includes a frame; a carriage slidably engaged with the frame and including a receptacle to receive a cartridge including fluidics ports and electronic contacts, the carriage slidable between an open position and a closed position; a fluidics interface to engage the fluidics ports of the cartridge when the carriage is in a closed position; an electronic interface to engage the electronic contacts of the cartridge when the carriage is in the closed position; a driver to draw the fluidics interface and the electronic interface together, the cartridge secured between the electronic interface and the fluidics interface; and a sensor system to detect the presence of the cartridge in the receptacle and configured to prevent the driver from drawing the fluidics interface and electronic interface together when the cartridge is absent.