Invention Application
- Patent Title: ANTIBODY-DRUG CONJUGATE (ADC) AND METHOD FOR FORMING THE SAME
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Application No.: US15341834Application Date: 2016-11-02
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Publication No.: US20170119902A1Publication Date: 2017-05-04
- Inventor: Yi-Ju KO , Jheng-Sian LI , Maggie LU , On LEE , Ping-Fu CHENG , Chun-Min LIU
- Applicant: Industrial Technology Research Institute
- Applicant Address: TW Hsinchu
- Assignee: Industrial Technology Research Institute
- Current Assignee: Industrial Technology Research Institute
- Current Assignee Address: TW Hsinchu
- Main IPC: A61K47/48
- IPC: A61K47/48

Abstract:
An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided. A-(L-D)p (I)
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