公开(公告)号：US20170119902A1

公开(公告)日：2017-05-04

申请号：US15341834

申请日：2016-11-02

Applicant: Industrial Technology Research Institute

Inventor： Yi-Ju KO ,  Jheng-Sian LI ,  Maggie LU ,  On LEE ,  Ping-Fu CHENG ,  Chun-Min LIU

IPC: A61K47/48

CPC classification number: C07K7/02 ,  A61K47/551 ,  A61K47/6817 ,  A61K47/6889 ,  C07K5/0207

Abstract: An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided. A-(L-D)p  (I)