公开(公告)号：US20170119902A1

公开(公告)日：2017-05-04

申请号：US15341834

申请日：2016-11-02

Applicant: Industrial Technology Research Institute

Inventor： Yi-Ju KO ,  Jheng-Sian LI ,  Maggie LU ,  On LEE ,  Ping-Fu CHENG ,  Chun-Min LIU

IPC: A61K47/48

CPC classification number: C07K7/02 ,  A61K47/551 ,  A61K47/6817 ,  A61K47/6889 ,  C07K5/0207

Abstract: An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided. A-(L-D)p  (I)

公开(公告)号：US20190106459A1

公开(公告)日：2019-04-11

申请号：US16216773

申请日：2018-12-11

Applicant: Industrial Technology Research Institute

Inventor： On LEE ,  Mei-Hsuan TSAI

IPC: C07K7/02 ,  A61K47/68 ,  A61K47/55 ,  C07K5/02

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.

公开(公告)号：US20180016300A1

公开(公告)日：2018-01-18

申请号：US15341117

申请日：2016-11-02

Applicant: Industrial Technology Research Institute

Inventor： On LEE ,  Mei-Hsuan TSAI

IPC: C07K7/02

CPC classification number: C07K7/02 ,  A61K47/551 ,  A61K47/6817 ,  A61K47/6889 ,  C07K5/0207

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.