- 专利标题： COUPLING ENDONUCLEASES WITH END-PROCESSING ENZYMES DRIVES HIGH EFFICIENCY GENE DISRUPTION
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申请号： US15215396申请日： 2016-07-20
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公开(公告)号： US20170152502A1公开(公告)日： 2017-06-01
- 发明人: Andrew M. Scharenberg , Michael T. Certo , Kamila Sabina Gwiazda
- 申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute )
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12N9/12 ; A61K38/46 ; A61K35/28 ; A61K9/00 ; C12N15/62 ; C12N9/22
摘要：
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
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