Technology relating to tuning for operating memory devices is disclosed. The technology includes a computing device that selectively configures operating parameters for at least one operating memory device based at least in part of performance characteristics for an application or other workload that the computing device has been requested to execute. This technology may be implemented, at least in part, in the firmware via a Basic Input/Output System (BIOS) or Unified Extensible Firmware Interface (UEFI) of the computing device. Further, this technology may be employed by a computing device that is executing workloads on behalf of a distributed computing system, e.g., in a data center. Such data centers may include, for example, thousands of computing devices and even more operating memory devices.