发明申请
- 专利标题： Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
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申请号： US15515574申请日： 2015-09-30
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公开(公告)号： US20170298017A1公开(公告)日： 2017-10-19
- 发明人: Bart Rudolf Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Dorothée Alice Marie-Eve BARDIOT , Arnaud Didier M MARCHAND
- 申请人： Janssen Pharmaceuticals, Inc. , Katholieke Universiteit Leuven
- 优先权： EPEP14187374.5 20141001; EPEP15159164.1 20150316
- 国际申请： PCT/EP2015/072551 WO 20150930
- 主分类号： C07D209/14
- IPC分类号： C07D209/14 ; A61K31/404
摘要：
The present invention concerns mono- or di-substituted indole derivatives (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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