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公开(公告)号：US20200339511A1
公开(公告)日：2020-10-29
申请号：US16088459
申请日：2017-03-31
发明人： Bart Rudolf, Romanie KESTELEYN , Pierre Jean-Marie, Bernard RABOISSON , Jean-François BONFANTI , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： C07D209/26 , A61K31/405 , A61K45/06 , A61P31/14 , A61K35/76
摘要： The present invention concerns substituted indoline compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination prepara-tions of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20180346419A1
公开(公告)日：2018-12-06
申请号：US15571930
申请日：2016-05-04
发明人： Bart Rudolf, Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo, Maria JONCKERS , Pierre Jean-Marie, Bernard RABOISSON , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： C07D209/14 , A61K45/06 , A61K31/404 , A61P31/14
摘要： The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20180002282A1
公开(公告)日：2018-01-04
申请号：US15542735
申请日：2016-01-15
发明人： Bart Rudolf, Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo, Maria JONCKERS , Pierre Jean-Marie, Bernard RABOISSON , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： C07D209/14 , A61K31/4045
CPC分类号： C07D209/14 , A61K31/4045 , C07B2200/13
摘要： The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20220409583A1
公开(公告)日：2022-12-29
申请号：US17777019
申请日：2020-11-13
发明人： Olivia Gabriella M. GOETHALS , Bart Rudolf Romanie KESTELEYN , Bart Henri Theresia STOOPS , Jean-François BONFANTI , Tim Hugo Maria JONCKERS , Marnix VAN LOOCK , Suzanne KAPTEIN , Johan NEYTS
IPC分类号： A61K31/4045 , A61P31/14
摘要： The present invention relates to the use of substituted indole derivatives and substituted indoline derivatives in the manufacture of a medicament for the treatment of dengue disease in an individual infected by dengue virus or the prevention of dengue disease in an individual at risk of being infected by Dengue virus. The invention further provides a method for the treatment or the prevention of dengue in an individual at risk of being infected by Dengue virus.
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公开(公告)号：US20190274999A1
公开(公告)日：2019-09-12
申请号：US16087800
申请日：2017-03-31
发明人： Bart Rudolf, Romanie KESTELEYN , Jean-François BONFANTI , Pierre Jean-Marie, Bernard RABOISSON , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： A61K31/404 , C07D209/32 , C07D209/12 , A61P31/14
摘要： The present invention concerns substituted indole derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20180256545A1
公开(公告)日：2018-09-13
申请号：US15759846
申请日：2016-09-15
发明人： Bart Rudolf, Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo, Maria JONCKERS , Pierre Jean-Marie, Bernard RABOISSON , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： A61K31/404 , A61P31/14
摘要： The present invention concerns mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections.The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20200270209A1
公开(公告)日：2020-08-27
申请号：US15930738
申请日：2020-05-13
发明人： Bart Rudolf Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Dorothée Alice Marie-Eve BARDIOT , Arnaud Didier M MARCHAND
IPC分类号： C07D209/14 , C07D209/04 , C07D471/08 , C07D487/08 , C07D513/08 , A61P31/14 , A61K31/404 , A61K45/06
摘要： The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20190112266A1
公开(公告)日：2019-04-18
申请号：US16088090
申请日：2017-03-31
发明人： Bart Rudolf, Romanie KESTELEYN , Pierre Jean-Marie, Bernard RABOISSON , Jean-François BONFANTI , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： C07D209/08 , A61P31/14
摘要： The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20180256544A1
公开(公告)日：2018-09-13
申请号：US15759844
申请日：2016-09-15
发明人： Bart Rudolf, Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo, Maria JONCKERS , Pierre Jean-Marie, Bernard RABOISSON , Dorothée Alice, Marie-Eve BARDIOT , Arnaud Didier, M MARCHAND
IPC分类号： A61K31/404 , A61P31/14
摘要： The present invention concerns mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections.The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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公开(公告)号：US20170298017A1
公开(公告)日：2017-10-19
申请号：US15515574
申请日：2015-09-30
发明人： Bart Rudolf Romanie KESTELEYN , Jean-François BONFANTI , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Dorothée Alice Marie-Eve BARDIOT , Arnaud Didier M MARCHAND
IPC分类号： C07D209/14 , A61K31/404
CPC分类号： C07D209/14 , A61K31/404
摘要： The present invention concerns mono- or di-substituted indole derivatives (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
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