- 专利标题: MACROCYCLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES
-
申请号: US15680729申请日: 2017-08-18
-
公开(公告)号: US20170342071A1公开(公告)日: 2017-11-30
- 发明人: Andrew K. Dilger , James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J.P. Pinto , Michael J. Orwat , Leon M. Smith, II
- 申请人: Bristol-Myers Squibb Company
- 主分类号: C07D471/18
- IPC分类号: C07D471/18 ; C07D487/08
摘要:
The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
信息查询