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公开(公告)号：US11352345B2
公开(公告)日：2022-06-07
申请号：US16954320
申请日：2018-12-18
发明人： Yan Shi , Peter Tai Wah Cheng , Hao Zhang , Jun Li , Tianan Fang , James R. Corte
IPC分类号： C07D403/14 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20210244711A1
公开(公告)日：2021-08-12
申请号：US17221859
申请日：2021-04-05
发明人： PETER TAI WAH CHENG , Robert F. Kaltenbach, III , Jun Li , Jun Shi , Yan Shi , Shiwei Tao , Hao Zhang , Suresh Dhanusu , Kumaravel Selvakumar , Ramesh Babu Reddigunta , Steven J. Walker , Lawrence J. Kennedy , James R. Corte , Tianan Fang , Sutjano Jusuf
IPC分类号： A61K31/4192 , C07D401/14 , C07D249/06 , A61K31/27 , A61K31/454 , C07D401/04
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US11053247B2
公开(公告)日：2021-07-06
申请号：US16451873
申请日：2019-06-25
发明人： Andrew K. Dilger , James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J. P. Pinto , Michael J. Orwat , Leon M. Smith, II
IPC分类号： C07D471/18 , C07F7/08 , C07D519/00 , C07D471/08 , C07D487/08
摘要： The present invention provides compounds of Formula (1): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20170158712A1
公开(公告)日：2017-06-08
申请号：US15437605
申请日：2017-02-21
发明人： Donald J. P. Pinto , James R. Corte , Paul J. Gilligan , Tianan Fang , Leon M. Smith, II , Yufeng Wang , Wu Yang , William R. Ewing
IPC分类号： C07D519/00 , C07D487/08 , C07D498/08 , C07D471/08
CPC分类号： C07D519/00 , C07D471/06 , C07D471/08 , C07D487/06 , C07D487/08 , C07D498/06 , C07D498/08
摘要： The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20160368923A1
公开(公告)日：2016-12-22
申请号：US15221142
申请日：2016-07-27
发明人： Andrew K. Dilger , James R. Corte , lndawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J.P. Pinto , Michael J. Orwat , Leon M. Smith II
IPC分类号： C07D471/18 , C07D519/00 , C07F7/08 , C07D487/08 , C07D471/08
CPC分类号： C07D471/18 , C07D471/08 , C07D487/08 , C07D519/00 , C07F7/0814
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 或立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US09453018B2
公开(公告)日：2016-09-27
申请号：US14872546
申请日：2015-10-01
发明人： Andrew K. Dilger , James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J. P. Pinto , Michael J. Orwat , Leon M. Smith, II
IPC分类号： C07D471/18 , C07D487/08 , C07B59/00 , C07D471/08 , C07D519/00
CPC分类号： C07D471/18 , C07D471/08 , C07D487/08 , C07D519/00 , C07F7/0814
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US20150203492A1
公开(公告)日：2015-07-23
申请号：US14419002
申请日：2013-08-02
发明人： Wu Yang , James R. Corte , Paul J. Gilligan , Donald J.P. Pinto , William R. Ewing , Andrew K. Dilger , Yufeng Wang , Tianan Fang , Kumar B. Pabbisetty , Leon M. Smith, II
IPC分类号： C07D471/08 , C07D401/04 , C07D487/08 , C07D471/18 , C07H17/02
CPC分类号： C07D471/08 , C07C53/18 , C07D401/04 , C07D471/18 , C07D487/08 , C07D487/18 , C07H17/02
摘要： The present invention provides compounds of Formula (X): (Formula (X), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（X）的化合物：（式（X））或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是选择性因子XIa抑制剂或FXIa的双重抑制剂 血浆激肽释放酶。本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US11319315B2
公开(公告)日：2022-05-03
申请号：US16772842
申请日：2018-12-18
发明人： Yan Shi , Peter Tai Wah Cheng , Ying Wang , Jun Li , Tianan Fang , James R. Corte , Jun Shi , Hao Zhang , Lawrence J. Kennedy , Shiwei Tao
IPC分类号： C07D401/14 , C07D403/14 , C07D417/14 , C07D413/14
摘要： The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20210230143A1
公开(公告)日：2021-07-29
申请号：US16772825
申请日：2018-12-18
发明人： Yan Shi , Ying Wang , Peter Tai Wah Cheng , Jun Shi , Shiwei Tao , James R. Corte , Tianan Fang , Jun Li , Lawrence J. Kennedy , Robert F. Kaltenbach, III , Sutjano Jusuf
IPC分类号： C07D401/14 , C07D409/14 , C07D403/14 , C07D401/12 , C07D405/14 , C07D491/052
摘要： The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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公开(公告)号：US20210078982A1
公开(公告)日：2021-03-18
申请号：US16954320
申请日：2018-12-18
发明人： Yan Shi , Peter Tai Wah Cheng , Hao Zhang , Jun Li , Tianan Fang , James R. Corte
IPC分类号： C07D403/14 , C07D417/14 , C07D413/14
摘要： The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.
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