Invention Application
- Patent Title: DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
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Application No.: US15683594Application Date: 2017-08-22
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Publication No.: US20170355963A1Publication Date: 2017-12-14
- Inventor: Alireza Rezania , Benjamin Fryer
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Main IPC: C12N5/071
- IPC: C12N5/071
Abstract:
The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.
Public/Granted literature
- US10421948B2 Methods for making pancreatic endocrine cells Public/Granted day:2019-09-24
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