- 专利标题： D-AMINO ACID DERIVATIVE-MODIFIED PEPTIDOGLYCAN AND METHODS OF USE THEREOF
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申请号： US15704977申请日： 2017-09-14
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公开(公告)号： US20180000929A1公开(公告)日： 2018-01-04
- 发明人: Carolyn R. Bertozzi , Mary Sloan Siegrist Palmore , John C. Jewett , Chelsea G. Gordon , Peyton Shieh
- 申请人： The Regents of the University of California
- 主分类号： A61K39/385
- IPC分类号： A61K39/385 ; A61K47/64 ; C12Q1/18 ; C12N1/20 ; C07K14/47 ; C07K9/00 ; C07K14/195 ; C12Q1/02 ; A61K39/00
摘要：
The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.
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