A method for obtaining self-cleaning and self-sanitizing surfaces of finished leather, comprising the steps of deposition of two coating layers containing respective active mixtures on the finished leather surface, in which a first active mixture comprises a film-forming compound based on polymers and filler, a flow additive compound, a cross-linking compound, an anti-oxidant compound and an aqueous dispersion, and a second active mixture comprises a water-based auxiliary flow additive compound, a silicone emulsion, a solvent aliphatic prepolymer, a photo-catalyst compound, a water repellent agent, a biocide action powder agent and solvent agents and/or wetting agents and/or dispersing agents and/or anti-foam agents.