Invention Application
- Patent Title: SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE
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Application No.: US15727220Application Date: 2017-10-06
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Publication No.: US20180071262A1Publication Date: 2018-03-15
- Inventor: Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Priority: CNPCT/CN2014/086792 20140918
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D498/10 ; C07D403/06 ; C07D493/10 ; C07D491/107 ; C07D263/52 ; C07D417/12 ; C07D417/04 ; C07D413/12 ; C07D413/04 ; C07D409/12 ; C07D407/12 ; C07D401/12 ; C07D235/02 ; C07D413/14 ; C07D403/12 ; C07D409/06 ; C07D405/06 ; A61K31/423 ; A61K31/4439 ; C07D401/06 ; C07D495/10
Abstract:
Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
Information query
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