- 专利标题： SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE
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申请号： US15727220申请日： 2017-10-06
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公开(公告)号： US20180071262A1公开(公告)日： 2018-03-15
- 发明人: Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
- 申请人： AbbVie Inc.
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 优先权： CNPCT/CN2014/086792 20140918
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; C07D498/10 ; C07D403/06 ; C07D493/10 ; C07D491/107 ; C07D263/52 ; C07D417/12 ; C07D417/04 ; C07D413/12 ; C07D413/04 ; C07D409/12 ; C07D407/12 ; C07D401/12 ; C07D235/02 ; C07D413/14 ; C07D403/12 ; C07D409/06 ; C07D405/06 ; A61K31/423 ; A61K31/4439 ; C07D401/06 ; C07D495/10
摘要：
Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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