发明申请
- 专利标题: METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETIDINONE COMPOUND
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申请号: US15835649申请日: 2017-12-08
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公开(公告)号: US20180099930A1公开(公告)日: 2018-04-12
- 发明人: Hua Bai , Xuyang Zhao , Yuncai Zhang , Xufei Li , Yong Zhang , Dezhou Xu , Li Zhang , Xiaojie Xu , Qifeng Zhu , Xiaoming Wang , Zhiqing Yang , Zehua Zhong , Jian Zhang
- 申请人: Zhejiang Hisun Pharmaceutical Co., Ltd.
- 申请人地址: CN Taizhou
- 专利权人: Zhejiang Hisun Pharmaceutical Co., Ltd.
- 当前专利权人: Zhejiang Hisun Pharmaceutical Co., Ltd.
- 当前专利权人地址: CN Taizhou
- 优先权: CN201410251262.5 20140609
- 主分类号: C07D205/08
- IPC分类号: C07D205/08 ; C07C59/56 ; C07C51/367 ; C07C67/327 ; C07C69/65 ; C07C67/343 ; C07C67/30 ; C07C69/732
摘要:
Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.