公开(公告)号：US12060324B2

公开(公告)日：2024-08-13

申请号：US17884959

申请日：2022-08-10

申请人： BioJiva LLC

发明人： Dragoslav Vidovic ,  Mikhail Sergeevich Shchepinov

IPC分类号： C07C67/30 ,  A61P1/16 ,  C07B59/00 ,  C07C5/00 ,  C07C11/12 ,  C07C29/00 ,  C07C51/347 ,  C07C69/587 ,  C07C407/00

CPC分类号： C07C67/30 ,  C07B59/001 ,  C07C5/00 ,  C07C11/12 ,  C07C29/00 ,  C07C51/347 ,  C07C69/587 ,  C07C407/00 ,  A61P1/16 ,  B01J2531/822 ,  C07B2200/05 ,  C07C2523/46 ,  C07C2531/22 ,  C07C2531/24 ,  C07C407/00 ,  C07C409/16 ,  C07C67/30 ,  C07C69/587 ,  C07C29/00 ,  C07C33/02 ,  C07C5/00 ,  C07C11/21

摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

公开(公告)号：US20240228736A1

公开(公告)日：2024-07-11

申请号：US18558643

申请日：2022-01-06

申请人： Agency for Science, Technology and Research

发明人： He-Kuan Luo

IPC分类号： C08J11/24 ,  C07C51/09 ,  C07C67/03 ,  C07C67/30

CPC分类号： C08J11/24 ,  C07C51/09 ,  C07C67/03 ,  C07C67/30 ,  C08J2367/02

摘要： The present invention relates to processes for depolymerizing a polyester of a dicarboxylic acid and for hydrolyzing a diester of terephthalic acid in the presence of a first base and a solvent mixture into a mono-salt of a monoester of the dicarboxylic acid and further comprises the further treatment of said mono-salt product into other useful derivatives, wherein the solvent mixture comprises at least one aprotic solvent and at least one protic solvent; and wherein the aprotic solvent and protic solvent are provided in a volume ratio of from 1:10 to 100:1. In a preferred embodiment, the aprotic solvent is dichloromethane (DCM), acetonitrile (ACN), tetrahydrofuran (THF) or diethyl ether; and the protic solvent is methanol, ethanol, or allyl alcohol; and the base is potassium hydroxide (KOH).

公开(公告)号：US20240092708A1

公开(公告)日：2024-03-21

申请号：US18521250

申请日：2023-11-28

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Kazunori Koide ,  James Proviano Burrows

IPC分类号： C07B31/00 ,  C07C41/20 ,  C07C51/347 ,  C07C67/30

CPC分类号： C07B31/00 ,  C07C41/20 ,  C07C51/347 ,  C07C67/30 ,  C07C2523/04

摘要： A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from −20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.

公开(公告)号：US20240018085A1

公开(公告)日：2024-01-18

申请号：US17884959

申请日：2022-08-10

申请人： BioJiva LLC

发明人： Dragoslav VIDOVIC ,  Mikhail Sergeevich SHCHEPINOV

IPC分类号： C07C67/30 ,  C07C5/00 ,  C07C407/00 ,  C07C29/00 ,  C07B59/00 ,  C07C69/587 ,  C07C51/347 ,  C07C11/12

CPC分类号： C07C67/30 ,  C07C5/00 ,  C07C407/00 ,  C07C29/00 ,  C07B59/001 ,  C07C69/587 ,  C07C51/347 ,  C07C11/12 ,  C07B2200/05 ,  C07C2523/46 ,  C07C2531/22 ,  C07C2531/24 ,  A61P1/16

摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

公开(公告)号：US11866386B2

公开(公告)日：2024-01-09

申请号：US17477900

申请日：2021-09-17

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Kazunori Koide ,  James Proviano Burrows

IPC分类号： C07B31/00 ,  C07C67/30 ,  C07C51/347 ,  C07C41/20

CPC分类号： C07B31/00 ,  C07C41/20 ,  C07C51/347 ,  C07C67/30 ,  C07C2523/04 ,  C07C51/36 ,  C07C61/22 ,  C07C41/20 ,  C07C43/188 ,  C07C51/36 ,  C07C61/39 ,  C07C51/36 ,  C07C61/28

摘要： A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from −20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.

公开(公告)号：US11453637B2

公开(公告)日：2022-09-27

申请号：US16708124

申请日：2019-12-09

申请人： Retrotope, Inc.

发明人： Dragoslav Vidovic ,  Mikhail Sergeevich Shchepinov

IPC分类号： C07B59/00 ,  C07C11/12 ,  C07C67/30 ,  C07C5/00 ,  C07C407/00 ,  C07C29/00 ,  C07C51/347 ,  C07C69/587 ,  A61P1/16

摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

公开(公告)号：US20220089508A1

公开(公告)日：2022-03-24

申请号：US17477900

申请日：2021-09-17

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Kazunori Koide ,  James Proviano Burrows

IPC分类号： C07B31/00 ,  C07C51/347 ,  C07C67/30

摘要： A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from −20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.

公开(公告)号：US10933409B2

公开(公告)日：2021-03-02

申请号：US16072192

申请日：2017-01-25

申请人： Seoul National University R&DB Foundation

发明人： Soon Hyeok Hong ,  Gunsoon Kim ,  Gitaek Song

IPC分类号： B01J31/22 ,  C07F15/00 ,  B01J31/16 ,  C07F15/06 ,  C07F15/02 ,  C07C67/333 ,  C07C201/00 ,  C07C29/00 ,  C07C67/30 ,  C07D207/20 ,  C07D207/48 ,  C07D211/96

摘要： Disclosed is a novel transition metal complex containing N-heterocyclic carbene and a sulfonamide group, or N-heterocyclic carbene and an amide group, and application thereof, the traquesnsition metal complex having a wider range of general purposes in olefin metathesis and being able to be variably controlled in reactivity.

公开(公告)号：US10858325B2

公开(公告)日：2020-12-08

申请号：US16126323

申请日：2018-09-10

申请人： MannKind Corporation

发明人： Kelly Sullivan Kraft ,  John J. Freeman ,  Paul Serwinski ,  Vincent Pavia ,  Otto Phanstiel ,  Navneet Kaur

IPC分类号： C07D241/06 ,  C07D241/08 ,  C07C201/12 ,  C07C67/39 ,  C07C67/30

摘要： Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphophoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

公开(公告)号：US20200223779A1

公开(公告)日：2020-07-16

申请号：US16641415

申请日：2018-09-12

申请人： Sirrus, Inc.

发明人： Jeffrey M. Sullivan ,  Ami Doshi ,  Kshitij Kishen Parab

IPC分类号： C07C67/30 ,  C07C45/61 ,  B01J31/04

摘要： The present teachings disclose contacting an amine salt catalyst with a dicarbonyl compound having an alkylene group between the carbonyl group; adding formaldehyde, paraformaldehyde, or formalin in an amount of about 2:1 to about 3:1 moles of formaldehyde to moles of the dicarbonyl compound to form a mixture; and refluxing the mixture. The process forms a carbonyl-substituted alkene. The process may be performed in the absence of a solvent. The process may form methylene malonates, methylene dimalonates, methylene keto malonamides, methylene diketones, methylene keto esters, and the like.