- 专利标题： SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS
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申请号： US15801123申请日： 2017-11-01
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公开(公告)号： US20180134719A1公开(公告)日： 2018-05-17
- 发明人: Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , David J. Bearss , Sunil Sharma
- 申请人： University of Utah Research Foundation
- 专利权人： University of Utah Research Foundation
- 当前专利权人： University of Utah Research Foundation
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D239/42 ; C07D239/48 ; C07D401/12
摘要：
In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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