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1.发明授权公开(公告)号：US09642857B2
公开(公告)日：2017-05-09
申请号：US14987460
申请日：2016-01-04
发明人： Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Bret Stephens , David J. Bearss , Sunil Sharma
IPC分类号： C07C251/86 , C07C311/16 , C07C311/37 , C07D207/48 , C07D213/53 , C07D213/61 , C07D213/71 , C07D213/81 , C07D231/12 , C07D295/26 , A61K31/18 , A61K31/40 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/5377 , A61K31/54
CPC分类号： A61K31/54 , A61K31/18 , A61K31/40 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/5377 , C07C251/86 , C07C311/16 , C07C311/37 , C07D207/48 , C07D213/53 , C07D213/61 , C07D213/71 , C07D213/81 , C07D231/12 , C07D295/26
摘要： Methods of treatment of disorders of uncontrolled cellular proliferation, including cancer, by administering substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds to mammals in need thereof.
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2.发明授权Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors 有权取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物作为酪氨酸受体激酶BTK抑制剂公开(公告)号：US09206176B2
公开(公告)日：2015-12-08
申请号：US14228184
申请日：2014-03-27
发明人： David J. Bearss , Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Sunil Sharma
IPC分类号： A61K31/505 , A61K31/519 , C07D239/42 , C07D239/48 , C07D487/04 , C07D471/04 , C07D239/30
CPC分类号： C07D239/48 , C07D239/30 , C07D239/42 , C07D471/04 , C07D487/04
摘要： In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作BTK激酶抑制剂的取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物来治疗与BTK激酶功能障碍相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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3.发明申请SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS 审中-公开取代（E）-N' - （1-苯基乙基）苯甲酰化酶类似物作为HISTONE DEMETHYLASE抑制剂公开(公告)号：US20150150864A1
公开(公告)日：2015-06-04
申请号：US14623370
申请日：2015-02-16
发明人： Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Bret Stephens , David J. Bearss , Sunil Sharma
IPC分类号： A61K31/4453 , A61K31/40 , A61K31/18 , A61K31/5377 , A61K31/5375 , A61K31/495 , A61K31/397
CPC分类号： A61K31/4453 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/495 , A61K31/5375 , A61K31/5377 , C07C311/16 , C07C311/46 , C07D205/04 , C07D295/155 , C07D295/26
摘要： In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作赖氨酸特异性组蛋白脱甲基酶（包括LSD1）的抑制剂的取代的（E）-N' - （1-苯基亚乙基）苯甲酰肼类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与LSD1功能障碍相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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4.发明授权Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors 有权取代的（E）-N' - （1-苯基亚乙基）苯甲酰肼类似物作为组蛋白脱甲基酶抑制剂公开(公告)号：US09555024B2
公开(公告)日：2017-01-31
申请号：US14623370
申请日：2015-02-16
发明人： Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Bret Stephens , David J. Bearss , Sunil Sharma
IPC分类号： C07C311/16 , C07C311/20 , C07C251/86 , C07C311/37 , C07C205/04 , C07C231/12 , A61K31/4453 , C07C311/46 , C07D205/04 , C07D295/155 , C07D295/26 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/495 , A61K31/5375 , A61K31/5377
CPC分类号： A61K31/4453 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/495 , A61K31/5375 , A61K31/5377 , C07C311/16 , C07C311/46 , C07D205/04 , C07D295/155 , C07D295/26
摘要： In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作赖氨酸特异性组蛋白脱甲基酶（包括LSD1）的抑制剂的取代的（E）-N' - （1-苯基亚乙基）苯甲酰肼类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与LSD1功能障碍相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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5.发明申请Substituted N-(3-(Pyrimidin-4-YL)Phenyl)Acrylamide Analogs as Tyrosine Receptor Kinase BTK Inhibitors 有权取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物作为酪氨酸受体激酶BTK抑制剂公开(公告)号：US20150368208A1
公开(公告)日：2015-12-24
申请号：US14433580
申请日：2013-10-04
发明人： Hariprasad Vankayalapati , Venkataswamy Soma , Steven L. Warner , David J. Bearss , Sunil Sharma
IPC分类号： C07D239/42 , C07D487/04 , C07F9/06
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61K31/661 , A61K31/6615 , C07D487/04 , C07F9/06 , C07F9/65583 , C07F9/6561
摘要： In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作BTK激酶抑制剂的取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物来治疗与BTK激酶功能障碍相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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6.发明申请SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS 有权取代的N-（3-（吡咯烷-4-基）苯基）丙烯酰胺类似物作为酪氨酸受体激酶激酶抑制剂公开(公告)号：US20150018349A1
公开(公告)日：2015-01-15
申请号：US14228184
申请日：2014-03-27
发明人： David J. Bearss , Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Sunil Sharma
IPC分类号： C07D471/04 , C07D239/48 , C07D239/30 , C07D239/42
CPC分类号： C07D239/48 , C07D239/30 , C07D239/42 , C07D471/04 , C07D487/04
摘要： In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作BTK激酶抑制剂的取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物来治疗与BTK激酶功能障碍相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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7.发明授权公开(公告)号：US09828376B2
公开(公告)日：2017-11-28
申请号：US14433579
申请日：2013-10-04
发明人： Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , David J. Bearss , Sunil Sharma
IPC分类号： C07D487/04 , C07D401/12 , C07D239/42 , C07D239/48
CPC分类号： C07D487/04 , C07D239/42 , C07D239/48 , C07D401/12
摘要： In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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8.发明申请公开(公告)号：US20170283397A1
公开(公告)日：2017-10-05
申请号：US15473073
申请日：2017-03-29
IPC分类号： C07D401/14 , C07D401/12
CPC分类号： C07D401/14 , C07D401/12
摘要： Substituted 1-H-indol-3-yl-benzamide and 1, 1′-biphenyl analogs derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1.
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9.发明申请公开(公告)号：US20160046586A1
公开(公告)日：2016-02-18
申请号：US14918322
申请日：2015-10-20
发明人： David J. Bearss , Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Sunil Sharma
IPC分类号： C07D239/48 , C07D239/42 , C07D239/30 , C07D471/04
CPC分类号： C07D239/48 , C07D239/30 , C07D239/42 , C07D471/04 , C07D487/04
摘要： In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20220119425A1
公开(公告)日：2022-04-21
申请号：US17422689
申请日：2020-01-15
IPC分类号： C07F9/09 , C07F9/38 , C07D213/73
摘要： Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.
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