An air-cooling heat dissipation device is provided for removing heat from the electronic component. The air-cooling heat dissipation device includes a base and an air pump. The base includes a top surface, a bottom surface, two lateral walls, a guiding chamber, an introduction opening and plural discharge grooves. The two lateral walls are connected between the top surface and the bottom surface. The introduction opening is formed in the top surface. The guiding chamber runs through the bottom surface and is in communication with the introduction opening. The discharge grooves are formed in one of the lateral walls and in communication with the guiding chamber. The plural discharge grooves are oriented toward the electronic component, so that a lateral air flow generated by the air pump is discharged through the discharge grooves and passes the electronic component to remove heat therefrom.