Technologies for processing network packets in an agent-mesh architecture include a network interface controller (NIC) of a computing device configured to write, by a network fabric interface of a memory fabric of the NIC, a received network packet to the memory fabric in a distributed fashion. The network fabric interface is configured to send an event message indicating the received network packet to a packet processor communicatively coupled to the memory fabric. The packet processor is configured to read, in response to having received the generated event message, at least a portion of the received network packet from the memory fabric, identify an agent of the NIC for additional processing of the received network packet, generate a network packet received event message indicating the received network packet is available for processing, and transmit the network packet received event message to the identified agent. Other embodiments are described herein.