- 专利标题： BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE
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申请号： US15919834申请日： 2018-03-13
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公开(公告)号： US20180207259A1公开(公告)日： 2018-07-26
- 发明人: Stephen C. HARRISON , Bing CHEN , Dan H. BAROUCH , Joseph P. NKOLOLA , Michael Scott SEAMAN
- 申请人： Beth Israel Deaconess Medical Center , Children's Medical Center Corporation
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07K14/005 ; C12N7/00 ; A61K39/00
摘要：
Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
公开/授权文献
- US10307478B2 Biochemically stabilized HIV-1 Env trimer vaccine 公开/授权日：2019-06-04
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