- 专利标题： NANOPARTICLES COMPRISING A METAL CORE SURROUNDED BY A MONOLAYER FOR LYMPH NODE TARGETING
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申请号： US15770442申请日： 2016-10-24
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公开(公告)号： US20180311174A1公开(公告)日： 2018-11-01
- 发明人: Darrell J. Irvine , Yu-Sang Sabrina Yang , Ahmet Bekdemir , Francesco Stellacci
- 申请人： Massachusetts Institute of Technology , École Polytechnique Fédérale de Lausanne
- 国际申请： PCT/US2016/058482 WO 20161024
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K47/69
摘要：
Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Active agent is bound thereto for use in vaccine and other adjuvant therapies, immunomodulation, and treatment of microbial infections, cancer, autoimmune disease, inflammation and inflammatory disorders.
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