Invention Application
- Patent Title: SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
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Application No.: US16025768Application Date: 2018-07-02
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Publication No.: US20180312485A1Publication Date: 2018-11-01
- Inventor: Taekyu Lee , Nicholas F. Pelz , Johannes Belmar , Zhiguo Bian , Edward T. Olejniczak , Stephen W. Fesik , Brian A. Chauder
- Applicant: Vanderbilt University
- Main IPC: C07D307/85
- IPC: C07D307/85 ; A61K31/5377 ; C07D401/14 ; A61K31/4155 ; A61K31/4439 ; A61K31/422 ; A61K31/4709 ; A61K31/404 ; A61K31/343 ; A61K31/381 ; C07D401/10 ; C07D413/10 ; C07D405/10 ; A61K45/06 ; C07D471/04 ; C07D413/12 ; C07D413/04 ; C07D409/04 ; C07D405/04 ; C07D403/14 ; C07D403/04 ; C07D401/06 ; C07D401/04 ; C07D405/14 ; C07D403/12 ; C07D209/42 ; C07D405/12 ; C07D401/12 ; C07D333/70 ; A61K31/496
Abstract:
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Information query
