- 专利标题: ANTITUMOR DRUG DELIVERY FORMULATION
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申请号: US15777498申请日: 2016-11-18
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公开(公告)号: US20180334674A1公开(公告)日: 2018-11-22
- 发明人: Yutaka KONDO , Keisuke KATSUSHIMA , Kazunori KATAOKA , Kanjiro MIYATA , Hyun Jin KIM
- 申请人: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY , THE UNIVERSITY OF TOKYO
- 优先权: JP2015-226895 20151119
- 国际申请: PCT/JP2016/084328 WO 20161118
- 主分类号: C12N15/113
- IPC分类号: C12N15/113 ; A61P35/00 ; A61K9/107 ; A61K47/69 ; A61K47/60 ; A61K47/64 ; A61K31/713
摘要:
This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.
公开/授权文献
- US11066665B2 Antitumor drug delivery formulation 公开/授权日:2021-07-20
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