公开(公告)号：US20180334674A1

公开(公告)日：2018-11-22

申请号：US15777498

申请日：2016-11-18

申请人： PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY ,  THE UNIVERSITY OF TOKYO

发明人： Yutaka KONDO ,  Keisuke KATSUSHIMA ,  Kazunori KATAOKA ,  Kanjiro MIYATA ,  Hyun Jin KIM

IPC分类号： C12N15/113 ,  A61P35/00 ,  A61K9/107 ,  A61K47/69 ,  A61K47/60 ,  A61K47/64 ,  A61K31/713

CPC分类号： C12N15/113 ,  A61K9/1075 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/76 ,  A61K47/34 ,  A61K47/60 ,  A61K47/6455 ,  A61K47/6907 ,  A61K48/00 ,  A61P35/00 ,  C12N15/00 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3231 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2320/32

摘要： This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.