PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

Invention Application

US20180339986A1 PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS 审中-公开

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Patent Title: PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS
Application No.: US16051879

Application Date: 2018-08-01
Publication No.: US20180339986A1

Publication Date: 2018-11-29
Inventor: Alexandre Joseph Buckmelter , Stephanos Ioannidis , Bruce Follows , Gary Gustafson , Minghua Wang , Justin A. Caravella , Zhongguo Wang , Edward L. Fritzen , Jian Lin
Applicant: FORMA Therapeutics, Inc.
Main IPC: C07D473/00
IPC: C07D473/00 ; A61K31/522

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

Abstract:

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

Public/Granted literature

US10399980B2 Purinones as ubiquitin-specific protease 1 inhibitors Public/Granted day:2019-09-03

Information query

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IPC分类:

C	化学；冶金
C07	有机化学
C07D	杂环化合物（高分子化合物入C08）
C07D473/00	含嘌呤环系的杂环化合物