公开(公告)号：US20220073525A1

公开(公告)日：2022-03-10

申请号：US17417805

申请日：2019-12-27

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Justin Andrew Caravella ,  Jian Lin ,  Edward L. Fritzen

IPC: C07D487/04

Abstract: This disclosure relates to modulating ubiquitin specific protease 1 (USP1) and provides novel chemical compounds useful as inhibitors of USP1, as well as various uses of these compounds. USP1 inhibiting compounds are useful in the treatment of diseases and disorders associated with USP1, such as cancer.

公开(公告)号：US11161848B2

公开(公告)日：2021-11-02

申请号：US16540327

申请日：2019-08-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US20220281869A1

公开(公告)日：2022-09-08

申请号：US17490482

申请日：2021-09-30

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin Andrew Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US20200079776A1

公开(公告)日：2020-03-12

申请号：US16540327

申请日：2019-08-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US12043623B2

公开(公告)日：2024-07-23

申请号：US17490482

申请日：2021-09-30

Applicant: Forma Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin Andrew Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

CPC classification number: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula:




where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US10399980B2

公开(公告)日：2019-09-03

申请号：US16051879

申请日：2018-08-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US20180339986A1

公开(公告)日：2018-11-29

申请号：US16051879

申请日：2018-08-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

CPC classification number: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US10189841B2

公开(公告)日：2019-01-29

申请号：US15355887

申请日：2016-11-18

Applicant: Forma Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: A61K31/522 ,  C07D473/00

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US20170145012A1

公开(公告)日：2017-05-25

申请号：US15355887

申请日：2016-11-18

Applicant: Forma Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00

CPC classification number: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.