An information handling system includes first processing resources, e.g., GPGPU expansion cards, in a first thermal region of the system and second processing resources, e.g., one or more CPUs, in a second thermal region. The system may be configured to perform operations including determining a loading profile of the system. The loading profile indicates power consumption information for each of the thermal regions. One or more thermal fans may be configured in accordance with a fan configuration associated with the loading profile. The fan configuration defines a fan speed and airflow direction for one or more thermal fans and determines, in accordance with the fan speed and airflow direction of each thermal fan, a rotational angle of one or more rotatable airflow guides. The rotational angle of a rotatable airflow guide influences thermal fan airflow provided to one or more of the thermal regions.