A transient signal protection circuit includes an input node coupled to a signal line configured to carry an output signal from a first circuit to a second circuit, wherein the signal line is subject to experiencing an unwanted reverse signal from the second circuit to the first circuit. The transient signal protection circuit also includes a comparator module configured to output a clamping signal when it is determined that the unwanted reverse signal includes a value that falls outside an acceptable range of the first circuit; and a power switch coupled to the comparator module and configured to couple the input node to a sink node when the comparator module outputs the clamping signal.