- 专利标题： PRODRUGGABLE ANTIBODIES, PRODRUGS THEREOF, AND METHODS OF USE AND MAKING
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申请号： US16103654申请日： 2018-08-14
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公开(公告)号： US20190055321A1公开(公告)日： 2019-02-21
- 发明人: Stanley R. Krystek, JR. , Yong Zhang , Gregory D. Vite , Arvind Rajpal , Chetana Rao-Naik , Paul E. Morin , Mohan Srinivasan , Zheng Lin , Virginie Lafont , Alla Pritsker
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 主分类号： C07K16/46
- IPC分类号： C07K16/46
摘要：
A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
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