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公开(公告)号：US11623965B2
公开(公告)日：2023-04-11
申请号：US16103654
申请日：2018-08-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stanley R. Krystek, Jr. , Yong Zhang , Gregory D. Vite , Arvind Rajpal , Chetana Rao-Naik , Paul E. Morin , Mohan Srinivasan , Zheng Lin , Virginie Lafont , Alla Pritsker
Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
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Patent Agency Ranking
公开(公告)号：US20230295346A1
公开(公告)日：2023-09-21
申请号：US18180998
申请日：2023-03-09
Applicant: BRISTOL -MYERS SQUIBB COMPANY
Inventor： Stanley R. Krystek, JR. , Yong Zhang , Gregory D. Vite , Arvind Rajpal , Chetana Rao-Naik , Paul E. Morin , Mohan Srinivasan , Zheng Lin , Virginie Lafont , Alla Pritsker
IPC: C07K16/46 , A61K39/395 , A61K47/60 , A61K47/65 , C07K16/28
CPC classification number: C07K16/464 , A61K39/39533 , A61K47/60 , A61K47/65 , C07K16/2818 , C07K16/2878 , A61P29/00 , C07K2317/24 , C07K2317/515 , C07K2317/76 , C07K2319/50
Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
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公开(公告)号：US08921542B2
公开(公告)日：2014-12-30
申请号：US13966613
申请日：2013-08-14
Applicant: Bristol-Myers Squibb Company
Inventor： Soong-Hoon Kim , Robert M. Borzilleri , Gregory D. Vite , James A. Johnson
IPC: C07D313/00 , C07D491/044 , C07D493/04 , C07D417/06 , C07D491/04
CPC classification number: C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
Abstract: The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
Abstract translation: 本发明涉及下列化合物，其中变量G，W，Q，X，Y，B1，B2，Z1，Z2和R1-R7如本文所定义，衍生物的制备方法及其中间体 。
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公开(公告)号：US20130331564A1
公开(公告)日：2013-12-12
申请号：US13966613
申请日：2013-08-14
Applicant: Bristol-Myers Squibb Company
Inventor： Soong-Hoon Kim , Robert M. Borzilleri , Gregory D. Vite , James A. Johnson
IPC: C07D491/044 , C07D417/06
CPC classification number: C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
Abstract: The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
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公开(公告)号：US20190055321A1
公开(公告)日：2019-02-21
申请号：US16103654
申请日：2018-08-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stanley R. Krystek, JR. , Yong Zhang , Gregory D. Vite , Arvind Rajpal , Chetana Rao-Naik , Paul E. Morin , Mohan Srinivasan , Zheng Lin , Virginie Lafont , Alla Pritsker
IPC: C07K16/46
Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
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公开(公告)号：US20150080440A1
公开(公告)日：2015-03-19
申请号：US14553081
申请日：2014-11-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Robert M. Borzilleri , Gregory D. Vite , James A. Johnson
IPC: C07D491/044 , C07D417/06
CPC classification number: C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
Abstract: The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
Abstract translation: 本发明涉及下列化合物，其中变量G，W，Q，X，Y，B1，B2，Z1，Z2和R1-R7如本文所定义，衍生物及其中间体的制备方法 。
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