![PROCESS FOR THE PREPARATION OF TRISODIUM (4-{[1S,3R)-1-([1,1'-BIPHENYL]-4-YLMETHYL)-4-ETHOXY-3-METHYL-4-OXOBUTYL]AMINO}-4-OXOBUTANOATE)-(N-PETANOYL-N-{[2'-(1H-TETRAZOL-1-1D-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL}- L-VALINATE) AND ITS POLYMORPHS THEREOF](/docs/US/2019-03-14/US20190077775A1/abs.jpg.600x600.jpg)
- 专利标题： PROCESS FOR THE PREPARATION OF TRISODIUM (4-{[1S,3R)-1-([1,1'-BIPHENYL]-4-YLMETHYL)-4-ETHOXY-3-METHYL-4-OXOBUTYL]AMINO}-4-OXOBUTANOATE)-(N-PETANOYL-N-{[2'-(1H-TETRAZOL-1-1D-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL}- L-VALINATE) AND ITS POLYMORPHS THEREOF
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申请号： US16083784申请日： 2017-03-06
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公开(公告)号： US20190077775A1公开(公告)日： 2019-03-14
- 发明人: Thirumalai Rajan SRINIVASAN , Eswaraiah SAJJA , Rajeshwar Reddy SAGYAM , Rajesham BOGE , Chkradhar NANDIGAMA , Srinivasa Rao AMBATI
- 申请人： MSN LABORATORIES PRIVATE LIMITED
- 优先权： IN201641007802 20160703; IN201641033544 20160930
- 国际申请： PCT/IN2017/000056 WO 20170306
- 主分类号： C07D257/04
- IPC分类号： C07D257/04 ; C07C233/47
![PROCESS FOR THE PREPARATION OF TRISODIUM (4-{[1S,3R)-1-([1,1'-BIPHENYL]-4-YLMETHYL)-4-ETHOXY-3-METHYL-4-OXOBUTYL]AMINO}-4-OXOBUTANOATE)-(N-PETANOYL-N-{[2'-(1H-TETRAZOL-1-1D-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL}- L-VALINATE) AND ITS POLYMORPHS THEREOF](/abs-image/US/2019/03/14/US20190077775A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a process for the preparation of Trisodium (4-{[(1S.3R)-1-([1,1′-biphenyl]-4-yl-methyl)-4-ethoxy-3-methyl-4-oxobutyl]amino}-4-oxo butanoate)-(N-pentanoyl-N-{[2′-(1H-tetrazol-1-id-5-yl)[1,1′-biphenyl]-4-yl]methyl}-L-valinate) represented by the following structural formula-1:
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