公开(公告)号：US20190077775A1

公开(公告)日：2019-03-14

申请号：US16083784

申请日：2017-03-06

申请人： MSN LABORATORIES PRIVATE LIMITED

发明人： Thirumalai Rajan SRINIVASAN ,  Eswaraiah SAJJA ,  Rajeshwar Reddy SAGYAM ,  Rajesham BOGE ,  Chkradhar NANDIGAMA ,  Srinivasa Rao AMBATI

IPC分类号： C07D257/04 ,  C07C233/47

CPC分类号： C07D257/04 ,  A61K9/10 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38 ,  B01D9/0022 ,  B01D9/0027 ,  C07B2200/13 ,  C07C231/12 ,  C07C233/47

摘要： The present invention relates to a process for the preparation of Trisodium (4-{[(1S.3R)-1-([1,1′-biphenyl]-4-yl-methyl)-4-ethoxy-3-methyl-4-oxobutyl]amino}-4-oxo butanoate)-(N-pentanoyl-N-{[2′-(1H-tetrazol-1-id-5-yl)[1,1′-biphenyl]-4-yl]methyl}-L-valinate) represented by the following structural formula-1:

公开(公告)号：US10093625B2

公开(公告)日：2018-10-09

申请号：US15509786

申请日：2015-09-08

申请人： MSN LABORATORIES PRIVATE LIMITED

发明人： Srinivasan Thirumalai Rajan ,  Sajja Eswaraiah ,  Komati Satyanarayana

IPC分类号： C07D211/22 ,  C07C51/06 ,  C07C51/367 ,  C07D263/24

摘要： The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate, represented by the following structural formula (I).

公开(公告)号：US20180244661A1

公开(公告)日：2018-08-30

申请号：US15553843

申请日：2016-02-26

申请人： MSN LABORATORIES PRIVATE LIMITED

发明人： SRINIVASAN THIRUMALAI RAJAN ,  Sajja ESWARAIAH ,  Chakilam NAGARAJU ,  Achampeta KODANDA RAMPRASAD ,  Peri SEETHA RAMA SARMA ,  Boge RAJESHAM

IPC分类号： C07D409/10 ,  A61K9/14

CPC分类号： C07D409/10 ,  A61K9/146 ,  C07B2200/13

摘要： The present invention relates to an improved process for the preparation of amorphous (1S)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol compound of formula-1, represented by the following structural formula:

公开(公告)号：US20180030043A1

公开(公告)日：2018-02-01

申请号：US15551856

申请日：2016-02-17

申请人： Srinivasan THIRUMALAI RAJAN ,  Sajja ESWARAIAH ,  Gutta MADHUSUDHAN ,  Komati SATYANARAYANA ,  Jakku MALLESWARA REDDY ,  MSN LABORATORIES PRIVATE LIMITED

发明人： Srinivasan THIRUMALAI RAJAN ,  Sajja ESWARAIAH ,  Gutta MADHUSUDHAN ,  Komati SATYANA RAYAMA ,  Jakku MALLESWARA REDDY

IPC分类号： C07D417/12 ,  A61K9/16 ,  A61K31/5377 ,  C07C271/20 ,  C07C269/04

CPC分类号： C07D417/12 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/1682 ,  A61K31/5377 ,  C07C269/04 ,  C07C271/20 ,  C07D277/28

摘要： The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.

公开(公告)号：US20220112212A1

公开(公告)日：2022-04-14

申请号：US17428745

申请日：2020-02-04

申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

发明人： Thirumalai Rajan SRINIVASAN ,  Eswaraiah SAJJA ,  Rajeshwar Reddy SAGYAM ,  Srinivasulu RAGINENI ,  Venkata Narasayya SALADI

IPC分类号： C07D498/14

摘要： The present invention relates to novel crystalline polymorphs of sodium (4R,12aS)-9-{[(2,4-difluorophenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5] pyrazino[2,1-b] [1,3] oxazin-7-olate represented by the following structural formula-1a and process for their preparation.
The present invention further relates to novel solvated forms of sodium (4R,12aS)-9-{[(2,4-difluoro phenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5] pyrazino[2,1-b][1,3] oxazin-7-olate compound of formula-1a and process for their preparation.

公开(公告)号：US11279696B2

公开(公告)日：2022-03-22

申请号：US16348791

申请日：2017-11-07

申请人： MSN LABORATORIES PRIVATE LIMITED

发明人： Thirumalai Rajan Srinivasan ,  Eswaraiah Sajja ,  Venkat Reddy Ghojala ,  Rajashekar Kommera

IPC分类号： C07D409/12

摘要： The Present Invention relates to process for the preparation of 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one represented by the following structural formula-1.

公开(公告)号：US10562931B2

公开(公告)日：2020-02-18

申请号：US15770118

申请日：2016-10-20

申请人： Srinivasan Thirumalai Rajan ,  Sajja Eswaraiah ,  Venkat Reddy Ghojala ,  MSN LABORATORIES PRIVATE LIMITED

发明人： Srinivasan Thirumalai Rajan ,  Sajja Eswaraiah ,  Venkat Reddy Ghojala

IPC分类号： A61K38/00 ,  C07K5/103 ,  C07K11/02 ,  C07K1/02

摘要： The present invention is relates to an improved process for the preparation (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabi-cyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone of formula I.

公开(公告)号：US20190177281A1

公开(公告)日：2019-06-13

申请号：US16099141

申请日：2017-05-02

申请人： Sromovasam THIRUMALAI RAJAN ,  Sajja ESWARAIAH ,  Sagyam RAJESHWAR REDDY ,  Macharla PRABHAKAR ,  Boge RAJESHAM ,  MSN LABORATORIES PRIVATE LIMITED

发明人： Srinivasan Thirumalai RAJAN ,  Eswaraiah SAJJA ,  Rajeshwar Reddy SAGYAM ,  Prabhakar MACHARLA ,  Rajesham BOGE

IPC分类号： C07D233/64

摘要： The present invention relates to an improved process for the preparation of 5-[[[(2S)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid compound of formula-1, and polymorphs thereof, the compound of formula-1 is further represented by the following structural formula:

公开(公告)号：US20190144411A1

公开(公告)日：2019-05-16

申请号：US16202840

申请日：2018-11-28

申请人： MSN Laboratories Private Limited

发明人： Srinivasan THIRUMALAI RAJAN ,  Sajja ESWARAIAH

IPC分类号： C07D309/10

摘要： The present invention provides a process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol which is represented by the following structural formula-1 and its glycerol solvate.

公开(公告)号：US20180312538A1

公开(公告)日：2018-11-01

申请号：US15770118

申请日：2016-10-20

申请人： MSN LABORATORIES PRIVATE LIMITED

发明人： Srinivasan Thirumalai RAJAN ,  Sajja ESWARAIAH ,  Venkat Reddy GHOJALA

IPC分类号： C07K5/103 ,  C07K1/02

CPC分类号： C07K5/101 ,  C07K1/02 ,  C07K11/02

摘要： The present invention is relates to an improved process for the preparation (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabi-cyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone of formula I.