发明申请
- 专利标题: NOVEL ESTERIFIED CELLULOSE ETHERS OF HIGH MOLECULAR WEIGHT AND HOMOGENEITY
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申请号: US16281700申请日: 2019-02-21
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公开(公告)号: US20190184020A1公开(公告)日: 2019-06-20
- 发明人: Oliver Petermann , Matthias Sprehe , Meinolf Brackhagen , Steven J. Guillaudeu
- 申请人: Dow Global Technologies LLC
- 主分类号: A61K47/38
- IPC分类号: A61K47/38 ; A61K9/10 ; C08B11/20 ; C08B13/00
摘要:
A process for making esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.
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