CELLULOSE ETHERS ESTERIFIED WITH DICARBOXYLIC ACID
    1.
    发明申请
    CELLULOSE ETHERS ESTERIFIED WITH DICARBOXYLIC ACID 有权
    用二羧酸测定的纤维素

    公开(公告)号:US20160289344A1

    公开(公告)日:2016-10-06

    申请号:US14777838

    申请日:2014-05-07

    摘要: Esterified cellulose ethers comprising groups of formula —C(O)—CHR′—CHR″—COOA, wherein, R′ and R″ are hydrogen or (—S)m (—R1)n-R2, wherein R1 is a hydrocarbon group having 1 to 4 carbon atoms, R2 is an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation, with the proviso that in each group CHR′—CHR″ one of R′ and R″ is hydrogen and the other one is (—S)m (—R1)n-R′, are useful as excipients for maintaining the concentration of poorly water-soluble drugs in aqueous liquids at supersaturation levels.

    摘要翻译: 包含式-C(O)-CHR'-CHR“-COOA基团的酯化纤维素醚,其中R'和R”是氢或(-S)m(-R1)n -R2,其中R1是烃基 具有1至4个碳原子,R 2是任选取代的5或6元环基,m和n各自独立地是0或1,A是氢或阳离子,条件是在CHR'-CHR “R”和R“之一是氢,另一个是(-S)m(-R1)nR',可用作在过饱和水平下维持水溶液中难溶于水的药物浓度的赋形剂。

    NOVEL ESTERIFIED CELLULOSE ETHERS OF HIGH MOLECULAR WEIGHT AND HOMOGENEITY
    3.
    发明申请
    NOVEL ESTERIFIED CELLULOSE ETHERS OF HIGH MOLECULAR WEIGHT AND HOMOGENEITY 审中-公开
    高分子量和均匀性的新型细胞纤维素

    公开(公告)号:US20150202301A1

    公开(公告)日:2015-07-23

    申请号:US14421064

    申请日:2013-08-15

    IPC分类号: A61K47/38 C08B13/00 A61K9/10

    摘要: Esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.

    摘要翻译: 酯化纤维素醚,其具有i)脂族一价酰基和式-C(O)-R-COOA基团的组合,其中R是二价脂族或芳族烃基,A是氢或阳离子,ii)重量 平均分子量Mw为80,000道尔顿至350,000道尔顿,iii)多分散性Mw / Mn为1.3至4.1,以及iv)粘度高达4.0mPa·s,以2.0wt%的酯化纤维素醚溶液 在20℃下0.43重量%的NaOH水溶液可用作药物剂型的肠溶性聚合物。

    ESTERIFIED CELLULOSE ETHERS HAVING A SPECIFIC SUBSTITUENT DISTRIBUTION
    4.
    发明申请
    ESTERIFIED CELLULOSE ETHERS HAVING A SPECIFIC SUBSTITUENT DISTRIBUTION 有权
    具有特殊取代分布的蛋白质酯

    公开(公告)号:US20150065547A1

    公开(公告)日:2015-03-05

    申请号:US14390041

    申请日:2012-10-24

    摘要: An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The esterified cellulose ether is useful as an excipient for poorly water-soluble drugs.

    摘要翻译: 酯化的纤维素醚包括(i)脂族一价酰基或(ii)式-C(O)-R-COOA的基团,其中R是二价脂族或芳族烃基,A是氢或阳离子或(iii) 脂族一价酰基和式-C(O)-R-COOA基团的组合,其中纤维素醚具有通过1-4键连接并具有甲基,羟基烷基和任选的烷基的脱水葡萄糖单元, 甲基作为取代基使得酯化纤维素醚具有0.05至1.00的MS(羟烷基),脱水葡萄糖单元的羟基被甲基取代,使得[s23 / s26-0.2 * MS(羟烷基)]为0.36以下, 其中s23是脱水葡萄糖单元的摩尔分数,其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代,其中s26是脱水葡萄糖单元的摩尔分数,其中仅th 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。 酯化纤维素醚可用作水溶性差的药物的赋形剂。

    Esterified cellulose ethers of low viscosity
    8.
    发明授权
    Esterified cellulose ethers of low viscosity 有权
    低粘度的酯化纤维素醚

    公开(公告)号:US09486532B2

    公开(公告)日:2016-11-08

    申请号:US14766997

    申请日:2014-02-28

    摘要: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs.

    摘要翻译: 酯化纤维素醚,其包含(i)脂族一价酰基或(ii)式-C(O)-R-COOA的基团,其中R是二价脂族或芳族烃基,A是氢或阳离子,或( iii)脂族一价酰基和式-C(O)-R-COOA基团的组合,其粘度高达2.33mPa·s,以2.0重量%的酯化纤维素醚溶液测量为0.43 20℃下的重量%NaOH水溶液,其粘度高达13mPao·s,以20wt%的酯化纤维素醚在丙酮中的10wt%溶液测量可用于制备包含药物的固体分散体 。