公开(公告)号：US10759873B2

公开(公告)日：2020-09-01

申请号：US15113921

申请日：2015-01-27

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen

IPC: C08B13/00 ,  A61K9/10 ,  A61K47/38 ,  A61K9/48 ,  C08B11/20 ,  A61K9/14 ,  A61K9/28

Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 220,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.0, and iv) an Mz/Mn of not more than 18.5, when the weight average molecular weight Mw, the number average molecular weight Mn and the z-average molecular weight Mz are measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaH2—PO4 and 0.1 M NaNO3. are useful as enteric polymers for pharmaceutical dosage forms.

公开(公告)号：US20170335018A1

公开(公告)日：2017-11-23

申请号：US15521028

申请日：2015-10-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe

IPC: C08B13/00

CPC classification number: C08B13/00 ,  A61K9/2866 ,  A61K9/2886 ,  A61K47/38 ,  C08L1/32 ,  C09D101/32

Abstract: A process for producing a cellulose ether acetate succinate comprises the step of reacting a cellulose ether with acetic anhydride, succinic anhydride and an depolymerizing agent, wherein the cellulose ether has an initial viscosity of at least 50 mPa-s, measured as a 2 weight-% solution in water at 20° C., and the reaction of the cellulose ether with acetic anhydride, succinic anhydride and the depolymerizing agent is conducted simultaneously or in sequence in one reaction device.

公开(公告)号：US09453081B2

公开(公告)日：2016-09-27

申请号：US14384220

申请日：2013-03-12

Applicant: Dow Global Technologies LLC

Inventor： Matthias Sprehe ,  Oliver Petermann ,  Robert B. Appell

IPC: C08B3/00 ,  C08B3/12 ,  C08B3/28 ,  C08B13/00 ,  C08B11/20

CPC classification number: C08B13/00 ,  C08B11/20

Abstract: A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s−1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.

Abstract translation: 反应产物混合物由（a）纤维素醚与（b）脂肪族单羧酸酐或二羧酸或三羧酸酐的反应或与脂族一元羧酸酐和二羧酸或三羧酸的组合 （c）脂族羧酸存在下的酸酐。 从该反应产物混合物中沉淀酯化纤维素醚的方法包括使反应产物混合物与水接触并使水和反应产物混合物的组合经受至少800s -1的剪切速率的步骤。 沉淀的酯化纤维素醚可以作为非粘性产物回收。

公开(公告)号：US09890220B2

公开(公告)日：2018-02-13

申请号：US14766609

申请日：2014-02-28

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Meinolf Brackhagen ,  Matthias Sprehe

IPC: C08B13/00 ,  C08B11/20 ,  C08L1/32 ,  A61K9/48 ,  A61K9/14 ,  A61K9/28

CPC classification number: C08B13/00 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/4816 ,  C08B11/20 ,  C08L1/32

Abstract: Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 220,000 Dalton, or which have a viscosity of up 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.

公开(公告)号：US20160347866A1

公开(公告)日：2016-12-01

申请号：US15113921

申请日：2015-01-27

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen

IPC: C08B13/00 ,  A61K9/10 ,  A61K9/48 ,  A61K47/38

CPC classification number: C08B13/00 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/4816 ,  A61K47/38 ,  C08B11/20

Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula ——C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 220,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.0, and iv) an Mz/Mn of not more than 18.5, when the weight average molecular weight Mw, the number average molecular weight Mn and the z-average molecular weight Mz are measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaH2—PO4 and 0.1 M NaNO3. are useful as enteric polymers for pharmaceutical dosage forms.

Abstract translation: 酯化纤维素醚，其具有i）酯基脂族一价酰基或脂族一价酰基的组合和式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是 氢或阳离子，ii）重均分子量Mw为80,000道尔顿至220,000道尔顿，iii）多分散性Mw / Mn为1.3至4.0，以及iv）Mz / Mn不大于18.5，当重量 平均分子量Mw，数均分子量Mn和z平均分子量Mz通过SEC-MALLS使用由40体积份乙腈和60体积份含有50mM NaH2-PO4和0.1M NaNO3。 可用作药物剂型的肠溶性聚合物。

公开(公告)号：US20150202301A1

公开(公告)日：2015-07-23

申请号：US14421064

申请日：2013-08-15

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen ,  Steven J. Guillaudeu

IPC: A61K47/38 ,  C08B13/00 ,  A61K9/10

CPC classification number: A61K47/38 ,  A61K9/10 ,  C08B11/20 ,  C08B13/00

Abstract: Esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.

Abstract translation: 酯化纤维素醚，其具有i）脂族一价酰基和式-C（O）-R-COOA基团的组合，其中R是二价脂族或芳族烃基，A是氢或阳离子，ii）重量 平均分子量Mw为80,000道尔顿至350,000道尔顿，iii）多分散性Mw / Mn为1.3至4.1，以及iv）粘度高达4.0mPa·s，以2.0wt％的酯化纤维素醚溶液 在20℃下0.43重量％的NaOH水溶液可用作药物剂型的肠溶性聚合物。

公开(公告)号：US20150031873A1

公开(公告)日：2015-01-29

申请号：US14384220

申请日：2013-03-12

Applicant: Dow Global Technologies LLC

Inventor： Matthias Sprehe ,  Oliver Petermann ,  Robert Bruce Appell

IPC: C08B13/00

CPC classification number: C08B13/00 ,  C08B11/20

Abstract: A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic mono-carboxylic acid anhydride and a di- or tri-carboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s−1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.

Abstract translation: 反应产物混合物由（a）纤维素醚与（b）脂肪族单羧酸酐或二 - 或三羧酸酐的反应或与脂肪族单羧酸酐和二 - 或三羧酸酐在（c）脂族羧酸存在下反应。 从该反应产物混合物中沉淀酯化纤维素醚的方法包括使反应产物混合物与水接触并使水和反应产物混合物的组合经受至少800s -1的剪切速率的步骤。 沉淀的酯化纤维素醚可以作为非粘性产物回收。

公开(公告)号：US10526421B2

公开(公告)日：2020-01-07

申请号：US15503600

申请日：2015-08-18

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Matthias Sprehe

IPC: C08B13/00 ,  C09D101/32 ,  C08L1/32 ,  A61K9/48 ,  A61K47/38 ,  A61K9/14 ,  A61K9/20

Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.

公开(公告)号：US20190184020A1

公开(公告)日：2019-06-20

申请号：US16281700

申请日：2019-02-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen ,  Steven J. Guillaudeu

IPC: A61K47/38 ,  A61K9/10 ,  C08B11/20 ,  C08B13/00

CPC classification number: A61K47/38 ,  A61K9/10 ,  C08B11/20 ,  C08B13/00

Abstract: A process for making esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.

公开(公告)号：US09745387B2

公开(公告)日：2017-08-29

申请号：US14420985

申请日：2013-08-15

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Yongfu Li ,  David M. Meunier ,  Oliver Petermann ,  Matthias Sprehe

IPC: C08B13/00 ,  C08B11/20 ,  A61K9/10 ,  A61K9/28 ,  A61K9/14

CPC classification number: C08B13/00 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2866 ,  C08B11/20

Abstract: A partially cross-linked esterified cellulose ether having A) groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and B) having a molecular weight distribution such that [Wf(>100 k)−Wf(>100 k)XL]/Wf(>100 k)XL is at least 0.20, wherein Wf(>100 k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>100 k)XL is the weight fraction that exceeds 100,000 g/mol of the methylated esterified cellulose ether is useful as enteric polymer for pharmaceutical dosage forms.